The Effects of Anti-angiogenesis on Enoxaparin Cutaneous Emulsion on Induced Breast Cancer in Female Rats

  • سال انتشار: 1397
  • محل انتشار: سومین کنگره بین المللی پزشکی شخصی ایران
  • کد COI اختصاصی: IPMCMED03_018
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 492
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نویسندگان

M Bolandpayeh

Department of Pharmacology& Toxicology, Faculty of Pharmacy, Pharmaceutical Branch ,Islamic Azad University, Tehran, Iran.(IAUPS)

M Hassanpour Ezzati

Department of Physiology, Faculty of Sciences School, Shahed University, Tehran, Iran

Z Mousavi

Department of Pharmacology& Toxicology, Faculty of Pharmacy, Pharmaceutical Branch, Islamic Azad University, Tehran, Iran.(IAUPS)

چکیده

Introduction: Studies have shown that there is a significant relationship between Heparin and female cancer. The present study examines the anti-angiogenesis effect of the enoxaparin skin lotion on breast cancer induced by dimethyl benzene anthracene.Methods: In this experimental laboratory study, 50 female rats were divided into intact, control and animals treated with enoxaparin (40, 60 and 80 mg %). After one month after, breast tissue samples were provided The immunohistological factors of VEGF and CD34 were studied . The data were analyzed using one-way analysis of variance (ANOVA).Results :. There was not any significant expression of these two factors in the control. Expression of both VEGF and CD34 increased with DMBA prescribing. Existing images indicate that Which is the intensity of red color in the tissues with increasing dosage Also, the intensity of the green color in the nucleus of the cells is also a symbol of intensityThe expression of these factors has also been diminishedConclusion: The results of this study demonstrate that enoxaparin has an inhibitory effect on the breast tumor size in a dose-dependent way; according to which, applying of enoxaparin in patients with breast cancer may have considerable role in considered in inhibition of tumor growth.

کلیدواژه ها

Enoxaparin, Breast Cancer, Female Rat

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