Uvasol attenuates cognitive impairment and astrocyte activation in pentylenetetrazol-induced kindling model of epilepsy
- سال انتشار: 1397
- محل انتشار: پانزدهمین کنگره بین المللی صرع ایران
- کد COI اختصاصی: EPILEPSEMED15_051
- زبان مقاله: انگلیسی
- تعداد مشاهده: 424
نویسندگان
Student Research Committee, Babol University of Medical Sciences, Babol, Iran
Cellular and Molecular Biology Research Institute, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
Cellular and Molecular Biology Research Center, Health Research Center, Babol University of Medical Sciences, Babol, Iran
چکیده
Background: Epilepsy is one of the most common chronic neurological disorders, which provoke progressive neuronal degeneration and memory impairment. In recent years, application of herbal compounds with anti-inflammatory properties, such as uvasol has been introduced as useful agent in reducing of the epilepsy symptoms. In this study, the effect of uvasol application on spatial memory improvement, neuronal density and astrocyte activation were evaluated in pentylenetetrazol (PTZ)-induced kindling model. Methods: Male NMRI mice have received the daily injection of uvasol at dose of 25 and 50 mg/kg.All interventions were injected intraperitoneally (i.p.), 10 days before PTZ administration and the injections were continued until 1 h before each PTZ injection. Spatial learning and memory was evaluated using Morris water maze test after the 11th PTZ injection. Animals have received 13 injections of PTZ and then, brain tissues were removed. Immunostaining against NeuN and GFAP respectively as mature neuronal and astrocyte markers were performed on brain sections. Findings:Our results showed that uvasol administration reduced the seizures behavior and prevented cognitive impairment in fully kindled animals. Immunostaining data demonstrated that the level of neuronal loss and astrocyte activation were reduced in animals under treatment of uvasol. Conclusion:Overall, the results of this study suggest that uvasol administration effectively ameliorates memory impairment and alleviates the level of neuronal death and astrocyte activation in PTZ-induced kindling model.کلیدواژه ها
Epilepsy; Uvasol; Spatial memory; Neuronal loss; astrocyte activationاطلاعات بیشتر در مورد COI
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