Asieh Vafaee, - Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Iran
Abolghasem Davoodnia, - Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Iran
Mohammad Reza Bozorgmehr, - Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Iran
Mehdi Pordel - Department of Chemistry, Mashhad Branch, Islamic Azad University, Mashhad, Iran

The success of COX-2 inhibitors containing a pyrazole moiety has highlighted the importance of these heterocyclics in medicinal chemistry [1]. Meanwhile, recent researches have shown the potency and selectivity of pyrazoline derivatives against B-RafV600E after being identified through high-throughput screening [2]. Both pyrazole and pyrazoline are reported to be backbone moieties of anti-cancer molecules [3]. These compounds are also reported to possess significant antipyretic, antidepressant, antiviral, antifungal, antitumor, and anti-inflammatory activities [4-6].Some new 4-acetamidoalkyl pyrazoles were synthesized by efficient, one-pot three-component reaction of 3,5-dimethyl-1-phenyl-1H-pyrazole or 3-methyl-1-phenyl-1H-pyrazol-5-ol, aromatic aldehydes and acetonitrile in the presence of chlorosulfonic acid at room temperature. The products were characterized on the basis of IR, 1H NMR, and 13C NMR data and evaluated as potential COX-2 and B-Raf inhibitors by molecular docking studies.