Electrochemical evidences in Drug-Drug interaction of acetaminophen with the Duloxetine and Fluvoxamine

Acetaminophen (1) is used worldwide for its analgesic and antipyretic properties. It is widely available and present in many prescription and non-prescription medications.It is an attractively alternative drug for children and people who are sensitive to aspirin [1]. Recently, we have dealt with the electrochemical oxidation of acetaminophen and 4-(Piperazin-1-yl)phenols in aqueous solution [2,3]. The oxidation of these compounds is followed by many chemical reactions such as hydrolysis, hydroxylation, and/or dimerization reaction [2, 3]. In this work with the aim of obtaining information about drug-drug interaction (DDI) we studied the electrochemical oxidation of acetaminophen (paracetamol) in the presence of Duloxetine and Fluvoxamine (3a,3b) (Figure 1) by means of cyclic voltammetry and Controlled-potential coulometry.Our results indicate the participation of electrochemically generated p-quinone imine (NAPQI) produced from electrooxidation of acetaminophen in Michael-type addition reaction with 3a,b. This reaction cause to reduce the concentration of NAPQI and decreases the effective concentration of these drugs. We would like to report a simple electrochemical procedure on the drug-drug interaction between acetaminophen and 3a,b and synthesis a new product of electrooxidation of acetaminophen in the presence of Fluvoxamine (3b) via ECECE mechanism under controlled potential conditions at biological pH and carbon electrode