Development of magnetic solid phase microextraction method for the determination of Diclofenac drug

In this research, magnetic solid phase microextraction is used as a sample preparation method for separation and preconcentration of diclofenac drug which was finally analyzed by UV-Vis spectrophotometry. By covalently linking dialdehyde starch and amine functionalized Fe3O4 nanoparticle, and modifying with arginine amino acid functional group, the novel monodisperse nano-composite has been successfully synthesized without any toxic crosslinking agent. The effective parameters, such as sample volume, salting effect, pH, surfactant amount and sorbent amount, desorption and extraction time were optimized with the aid of response surface methodology (RSM) and experimental design. [1,2]. Factors including; pH, sample volume and salting effect had the greatest effect on the process.The optimum conditions for these parameters were2.20,13ml and 7.42% respectively.The limits of detection was 0.039 mgL-1 Under the optimized conditions, the pre-concentration factors are 148.