Preparation of porous hydrogel beads based on calcium-ion-crosslinked gum tragacanth/graphene oxide: Swelling and drug delivery behavior

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 279

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شناسه ملی سند علمی:

IRANCC20_231

تاریخ نمایه سازی: 28 اردیبهشت 1398

چکیده مقاله:

During the past few decades, naturally derived materials have attracted much attention for development of various drug delivery systems [1]. Natural polysaccharides are preferred for drug delivery systems because of their easy availability, cost effectiveness, biodegradability and biocompatibility [2]. Preparation of ionic hydrogels with polysaccharide give interesting properties related to their polyelectrolytic nature of the structure. Bernela et al. reported ionic gelation method for synthesis of bromelain loaded tragacanth gum (katira gum) nanoparticles [3]. Composite hydrogels improve the drug encapsulation, mechanical strength, and controlled drug release with the addition of amplifying organic/inorganic fillers such as nano-clay, GO, carbon nanotubes and using blends of different polymers [4]. In this work, the objective was to prepare porous hydrogel beads from polysaccharide gum tragacanth (GT) and graphene oxide (GO) via ionic- crosslinking agent without using synthetic monomer The in vitro drug release studies from the prepared hydrogel beads exhibited significant behaviors on the subject of physiological-simulated pH values. The maximum cumulative releases were 97.62% and 42.2% at the pH values of 7.4 and 1.2, respectively.

نویسندگان

Zeinab Rahmani

Department of Organic Polymer Chemistry, Faculty of Chemistry, Mazandaran University, Babolsar, Iran

Mousa Ghaemy

Department of Organic Polymer Chemistry, Faculty of Chemistry, Mazandaran University, Babolsar, Iran