Anticancer activity of three novel Pt complexes with Amine and glycine ligand

Using bidentate ligand such as amino acid derivatives is the strategy in designing new drugs.Due to presence of lipophilic functional group, toxicity of drug is reduced and influence of the drug into the cancer cell is improved [1]. Recently, three anticancer complexes were synthesized with formula of cis-[Pt(Butylamine)2(Butylglycine)]NO3, cis-[Pt(Isopentylamine) 2(Iso-pentylglycine)]NO3 and cis-[Pt(Tert-pentylamine)2(Tertpentylglycine)] NO3. These compounds (Fig. 1) have been characterized using analytical andspectroscopic methods such as elemental analysis, conductivity, FT-IR, UV-Vis and 1H-NMR techniques. These water soluble complexes show 50% cytotoxic concentration (Cc50) values against cell line, at micro molar concentration higher than cisplatin activity [2].