Razieh Hosseini - Department of Chemistry, Faculty of Science, Vali-e-Asr University, Rafsanjan
Reza Ranjbar Karimi - Department of Chemistry, Faculty of Science, Vali-e-Asr University, Rafsanjan
Kazem Mohamadian nejad - Department of Chemistry, Faculty of Science, Vali-e-Asr University, Rafsanjan

There has been an increasing interest in discovering and developing small molecules that are of pharmaceutical importance. Heterocyclic compounds are known to be themost versatile class of these types of molecules, either prepared synthetically or occurring in nature. However, in some cases, it has been reported that the activity isenhanced to a larger extent when these heterocycles are repeated in the molecule separated by a suitable spacer, bis-heterocycle. Thus, the synthesis of new bisheterocycliccompounds has become an eye-catchy field to explore in the recent past owing to their pharmacological, biological and industrial importance [1]. The synthesis of bis-heterocycles is mainly achieved by joining heterocyclic nuclei together using a variety of linkers and points of linkages. Pentafluoropyridine has attracted considerable interest due to its synthetic utility [2]. In this work, we report our investigations on the reaction of pentafluoropyridine 1 with Sulfamide 2 in the presence of potassium carbonate as a base and acetonitrile as a solvent following a literature procedure (Scheme 1). Various derivatives of these compounds were synthesized in good to excellent yields. The products were purified by plate chromatograghy using appropriate solvent systems, and the structures were established by NMR and IR spectral data.