Novel efficient heterogeneous copper (‖) nanoparticles for the synthesis of 1-and 5- substituted 1H tetrazoles

Tetrazoles are an important class of the synthetic heterocyclic compounds with wide range of practical applications in major areas of sciences such as medicine, chemistry and material sciences. From pharmaceutical chemistry viewpoint, tetrazole derivatives have many biological activities such as antihypertensive,1 anti-allergic,2 antibiotic,3 anti-diabetic,4 anti-arrhythmic,5 activity and have also potential for drug developmentas inhibitor for HIV or other immune diseases.tetrazole rings can be prepared in several ways.the most convenient rout for preparation of 5-substituted 1H-tetrazol is via mixture of amine (2 mmol),sodim azide (2 mmol),triethyl ortho – format(2 mmol), Fe3O4@SiO2/ liganad /cu (ǁ) catalyst(0.05 gr) was taken in a roundbottomed flask and stirred at 100 ˚C under solvent free condition.the stable, green, recyclable, inexpensive catalyst was removed by using magnetic field and then the resulting solution was washed with water.this method gives notable advantages such as easy separation, excellent yields, short reaction times,non- toxic metal catalyst and simplicity of operation make method a facile tool for the synthesis of tetrazoles.

کلیدواژه ها:

5- substituted 1H tetrazoles ، sodium azide ، triethyl ortho- formate