synthesis of 1-and 5- substituted 1H tetrazoles catalyzed by separable ligand complex of copper (ǁ) supported on Fe3O4@SiO2 nanoparticles

Simple and efficient procedure for the synthesis of 5-substituted 1H-tetrazole derivatives has been developed by one-pot three-component reaction with (0.05 gr, 2mmol, 2mmol, 2mmol) ratio of Fe3O4@SiO2/ liganad /cu (‖) catalyst, amin, sodium azide and triethyl ortho-formate under solvent free conditions at 100 ˚C.This catalyst is thermally stable, green, recyclable, inexpensive, and easy to prepare. In addition, it can be easily separated from the reaction mixture and recycled up to five times without any significant impact on its activity or the reaction yield. The operational simplicity, high yields, and facile work‐up procedures associated with this catalytic process giveit advantages over.

کلیدواژه ها:

5- substituted 1H tetrazoles ، sodium azide ، triethyl ortho- formate