Hoda Mollabagher - Chemistry and Chemical Engineering Research Center of Iran (CCERCI), PO Box ۱۴۳۳۵-۱۸۶,Tehran, Iran.
Salman Taheri - Chemistry and Chemical Engineering Research Center of Iran (CCERCI), PO Box ۱۴۳۳۵-۱۸۶,Tehran, Iran.

Benzothiazole nucleus structures, are main classes of organic compounds in the pharmaceutical industry. The benzimidazole moieties are found in several synthetic drugs, exhibiting an extensive spectrum of biological activities, including anti-cancer, anti-tumour and anti-fungal [1]. Riluzole with benzothiazole core is used to treat a certain type of nerve disease called amyotrophic lateral sclerosis [2]. General synthetic procedures for the synthesis of Riluzole include the reaction of 4- (trifluoromethoxy)aniline derivatives with ammoniumthiocyanat [3] or potassiumthiocyanate [4] in the presence of oxidant for cyclization. In this research, 4-(trifluoromethoxy)aniline reacted with ammoniumthiocyanat in acetic acid in the presence of a Potassium persulfate at a low temperature for appropriate time to afford the 6-(trifluoromethoxy)benzo[d]thiazol-2-amine,after completing the reaction the mixture are basified with ammonia and the crude recrystallize in toluene and cyclohexane. This method can be used and generalizedin pharmaceutical industry.