The effect of probiotic Lactobacillus on the control of weight and on serum leptin and adiponectin status in streptozotocin-induced diabetic rats

Diabetes is of the most prevalence glands illnesses throughout the world which happens at the result of a deficiency of insulin secretion or insulin action or sometimes both of them. Adiponectin and leptin are proteins secreted from adipose tissue and influence on some of the effective factors in diabetes including fatness and insulin resistance. Probiotic bacteria are of the dietary supplements that have useful effects on human health. The main purpose of this research was to investigate the effects of probiotic lactobacillus on weight control, leptin and adiponectin status in streptozotocin-induced diabetic rats. In this research 32 male rats of Wistar race were divided randomly into 4 groups of 8 sets. First group: normal control, which was fed only by standard food and 0/2 ml phosphate-buffered saline daily. Second group: normal control with lactobacillus that received 109cfu/ml lactobacillus by gavage and standard food daily. Third group: the diabetic group (using streptozotocin) that were fed only by 30 g of fatty food daily. Fourth group: diabetic group with lactobacillus received 109cfu/ml lactobacillus by gavage in addition to fatty food diet. After the treatment period (6 weeks), a liquid profile in the blood was measured. The results showed that probiotic lactobacillus in diabetic rats with lactobacillus in proportion to diabetic control, could decrease the serum level of leptin significantly (p<0.05) and increase the serum level of adiponectin and rats’ weight significantly (p<0,05). By considering the results, it was defined that the probioticlactobacillus can influence adiponectin and leptin and also the overweight caused by diabetes.

کلیدواژه ها:

Lactobacillus ، Probiotic ، Leptin ، Adiponectin ، Diabetes