Investigating the anti-Alzheimer s properties of Desf: studying the inhibitory effects of the Desf extract on the production of amyloid nanobiofibrils and measuring its antioxidant activity

Desf, known as Heracleum persicum and the English name Desf, is a flowering plant and perennial and which is from the Apiaceace family. This plant grows in the mountainous regions of Iran and despite the various antioxidants among pimpinellin, It can have significant therapeutic effects in the treatment of Alzheimer s disease. The purpose of this study is to investigate the anti-Alzheimer s properties of Desf by the inhibitory effect of the Desf extract on the production of amyloid nanobiofibrils and measuring the antioxidant activity of Desf. Firstly, powdered Desf and with using 96% ethanol, The hydroalcoholic extract of the product was prepared. The anti-Alzheimer s effect of Desf was investigated by investigating the inhibitory effect of Desf extract on the production of amyloid nanobiofibrils from bovine serum albumin as a protein model, At concentrations of 0/4, 0/8, 1/2, 1/6 and 2 mg/ml the extract was examined by spectrophotometry method and the percentage of antioxidant activity in doses of 1 to 10 mg/ml was determined by the DPPH method. It was found that hydroalcoholic extract of Heracleum persicum had the most inhibitory effect on the production of amyloid strands at a concentration of 1/6 mg/ml and the highest antioxidant activity was observed at 3 mg/ml of extract. Inhibition of the production of amyloid strands and antioxidant effect, they confirm the anti-Alzheimers properties of the Heracleum persicum and it can be introduced as one of the most effective medicines to reduce the effects of Alzheimer s disease in humans.

کلیدواژه ها:

Desf ، Anti-Alzheimer ، Amyloid nanobiofibrils ، Bovine serum albumin