Investigating the conformity of the second law of Chargaff on variable-length homopolymer fragments in the human genome
سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 393
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شناسه ملی سند علمی:
BIOCONF20_502
تاریخ نمایه سازی: 28 اردیبهشت 1398
چکیده مقاله:
Chargaff studies on thefour DNAnucleotides showed that the frequency of A and C is equal to T and G respectively in an organism s genome. This equality in the doublestranded DNA known as Chargaff s first law, which is the result of the formation of The Watson-Creek pairing in the double-helix structure of DNA.The Chargaff s second rule states that the first rule also holds in ssDNA. These tworulescover all the double-stranded genomesexcept organelle genomes1. In this study, we have analyzed the human genome to investigate the evidence of a generalized form of the Chargoff s second rule. Interestingly enough, results reveal that the frequency of the A and C homopolymers is equal to the frequency of T and G homopolymers, respectively.
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نویسندگان
Reza Sotoudeh
Department of Nanobiotechnology/Biophysics, Faculty of Biological Science, Tarbiat Modares University, Tehran, Iran
Javad Zahiri
Bioinformatics and Computational Omics Lab (BioCOOL), Department of Biophysics, Faculty of Biological Science, Tarbiat Modares University, Tehran, Iran