The effect of simulated microgravity on RKIP tumor suppressor gene expression in MCF-7 breast cancer cell line

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 232

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شناسه ملی سند علمی:

BIOCONF20_479

تاریخ نمایه سازی: 28 اردیبهشت 1398

چکیده مقاله:

The living organisms on the surface of the earth are affected by the natural gravity force (1g) and if this gravitational force undergoes changes, it will surely be under the influence of a unique shock and make changes to accommodate it. Weightlessness exerts exhibitiveeffects on cell functions by participation with biochemical pathways and gene expressions and study of these alterations would be beneficial to aid astronauts and improving the quality of human life. It has been shown that in simulated microgravity, the expression of some genes and protein levels produced in cultured cells or laboratory animals have been altered. However, very little information is available on the effects of simulated microgravity on the gene expression. Raf kinase inhibitory protein (RKIP) is a regulator of kinase activity and a cell balancing agent that also acts as a metastatic inhibitor in a variety of solid tumors, including breast cancer, and has diverse physiological functions. Overall, RKIP expression in progressive tumors is reduced and its increase decreases the invasive potency of cancer cells without affecting primary tumor growth. In this study, we investigated the changes of RKIP gene expression in human MCF-7 breast cancer cells after 24 and 72 hours exposure to microgravity conditions. Our consequences show that microgravity has altered the expression levels of RKIP gene. In summary, microgravity is a valuable instrument for prospecting new aims in cancer therapy and can be simulated in some aspects in ground-based conditions.

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نویسندگان

Maryam Salavatifar

Space biology and Environment Center, Aerospace Research Institute, Ministry of Science, Research and Technology, Tehran, Iran