The effect of different coating surface on Silver nanoparticles interaction with human serum album (HSA)

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 373

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شناسه ملی سند علمی:

BIOCONF20_431

تاریخ نمایه سازی: 28 اردیبهشت 1398

چکیده مقاله:

Among the inorganic nanoparticles, silver nanoparticles (Ag NPs) has been utilized most widely in the nanotechnology and medical industry due to its antiinfections and anti-tumor activities. The aim of this study is to evaluate the effects of Polyethylene glycol (PEG) and Sodium citrate coating on Ag NPs interaction with human serum albumin (HSA) with Fluorescence spectroscopy, Fourier-transform infrared spectroscopy (FTIR) and Zeta potential studies. The Fluorescence data and binding constants dewohsthat PEG-coated Ag NPs could interact with HSA more strongly and make structural changes compare with Sodium citrate-coated Ag NPs. FTIR studies and Zeta-potential analysis also confirmed the structural changes of HSA after interaction with PEG-coated Ag NPs strongly. The results obtained from this study proffer a good strategy for designing new drugs and standardization in nanotechnology

کلیدواژه ها:

Human serum albumin (HSA) ، PEG-coatedsilver nanoparticles ، Sodium citrate coated- silver nanoparticles

نویسندگان

Zahra Roshani

Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran

Azadeh Hekmat

Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran

Mohammad Yousefi

Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran