Anti-proliferative effects of the nano-oxalipalladium complex in comparison with oxalipalladium against human colon cancer cell line of HCT116
سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 414
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شناسه ملی سند علمی:
BIOCONF20_341
تاریخ نمایه سازی: 28 اردیبهشت 1398
چکیده مقاله:
Platinum (II) complexes are widely used in the treatment of several human malignant diseases, such as colon cancer. Previous reports have represented several disadvantages of cis-platin particularly related to general toxicity which leads to undesirable side effects and to drug resistance phenomena limit its clinical application. Recently, Pd(II) analogues were considered as anti-tumor drugs due to its structural similarities between Pd and Pt, as well as low toxicity. So, in the present study, we have investigated the anti-cancer activity and death induce ability of a newly synthesized nano-oxali-palladium using ginger extract and free oxali palladium by (MTT) assay after 24 and 48 hours incubation times. The 50% cytotoxic concentrations (Cc50) of nano-oxali-palladium were determined 32.5 and 18 μM after 24 and 48 hours incubation times, respectively. On the other hand, this value was evaluated 600 and 433 μM for free oxali-palladium after 24 and 48 h incubation times. Also, 13 and 18 mg/ml of ginger extract after 24 and 48 hours incubation times, were induced 50% death in HCT116 colon cancer cell line. Above results show that the newly synthesized nano-oxali-palladium using ginger extract has a more cytotoxic effect on colon cancer cell line after 24 and 48 h incubation times. Also, the anticancer activity of ginger extracts used in nanooxali-palladium increases the cytotoxicity of this compound
کلیدواژه ها:
نویسندگان
Mahdieh Kooshki
Department of Cell & Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran
Adeleh Divsalar
Department of Cell & Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran
Saied Ayerian
Department of Cell & Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, Iran
Arefeh Seyed Arabi
Institute of Biochemistry and Biophysics,.University of Tehran,Tehran,Iran