Anti-diabetic effects of ZnO nanoparticles synthesized by Eryngium billardieri aqueous extract on diabetic rats

Nanotechnology is a discipline of applied knowledge. The progress and efficiency of the green synthesis method in the use of natural reducers, fixation of final materials without the use of toxic agents, lack of energy consumption and improvement of the properties of the materials provided. Diabetes is a chronic disorder in carbohydrate metabolism, fat, and protein, and is characterized by increased blood glucose levels in the patient. Cardiovascular failure, renal failure, and decreased neurological activity are the long-term complications of this disease. Eryngium billardieri is a perennial herb of the Apiaceae family. This genus contains tannin, saponins, alkaloids, flavonoids, and beta-carotene. The element of micronutrient zinc (Zn) is essential for a variety of biological processes, including glucose metabolism. In this study, ZnO nanoparticles were synthesized by chemical and biological methods using an aqueous extract of E. billardieri, and their anti-diabetic effects on diabetic rats were investigated. Structural properties of nanoparticles were investigated using XRD, TGA, UV-vis DRS, FT-IR and SEM analyze. The size of nanoparticles synthesized by biochemical methods, 21.5 nm, was determined to decrease the size of the nanoparticles synthesized by the chemical method (25 nm). Also, the presence of plant extract molecules with zinc oxide prepared by these techniques was confirmed. Injection dose was determined for groups receiving nano-materials, 10 mg/kg body weight. The results indicate a significant reduction infasting blood sugar in the recipient group of bioavailable nanoparticles compared to the control group (p<0.05).

کلیدواژه ها:

Diabetes ، Eryngium billardieri ، Green Synthesis ، Zinc oxide nanoparticles