Orexinergic system and acquisition of conditional fear memory in male PTSD rats
- سال انتشار: 1397
- محل انتشار: بیستمین کنگره ملی و هشتمین کنگره بین‌المللی زیست‌شناسی ایران
- کد COI اختصاصی: BIOCONF20_009
- زبان مقاله: انگلیسی
- تعداد مشاهده: 487
نویسندگان
School of Biology, Damghan University, Damghan, Iran
School of Biology, Damghan University, Damghan, Iran
School of Biology, Damghan University, Damghan, Iran
چکیده
The remarkable feature of PTSD is changes in structure and function of the brain, especially the most important structures are medial prefrontal, hippocampus and amygdala. Orexinergic neurons that located in lateral hypothalamus carry extensive projections to these areas. The Orexinergic system is involved in the acquisition of fear memories. The aim of this study is to investigate the role of this system in acquisition of fear memory in PTSD rats. In this study the wistar rats were implanted with bilateral cannula in the amygdala for micro- injection of orexin receptor-1 antagonist (SB334867), orexin receptor-2 antagonist (TCSOX229), the solvent of SB334867 and the solvent of TCSOX229, respectively in 4 experimental groups; SB, TC, SB control and TC control groups. One week after the surgery single prolonged stress (SPS) method used to develop PTSD in rats. A week later rats were conditioned by receiving electrical foot shock in fear conditioning system then immediately after the shock they received microinjection of drugs. The day after, the freezing behavior, as an indicator of memory extinction, was evaluated in 3 continuous days. Control rats showed a freezing of 80 to 90 percent in the first extinction test. This percent dropped by about 70 in the third test. SB334867 and TCSOX229 significantly decreased the freezing behavior in SB, TC groups as compared with SB control and TC control groups respectively. This decrease was sustained in all three consecutive tests. Decreasing in freezing behavior in memory tests indicates the formation of memory extinction in PTSD rats and since antagonists were injected before conditioning, this effect applies through interference with the acquisition of fear memory. Findings of this study verified the role of orexin receptors 1 and 2 in acquisition of contextual fear memory in PTSD rats and that inhibition of this system results in fear extinction.کلیدواژه ها
Post-traumatic Stress disorder, Extinction,Acquisition, Orexin, Amygdalaمقالات مرتبط جدید
- بررسی خاصیت ضدبیوفیلمی ترکیب گیاهی ۱و۸-سینئول علیه آسینتوباکتر بومانی دارای مقاومت داروئی
- ابر دریاچه باستانی ری - مقدمه ای بر تغییرات سطح-حجم آب در طول زمان از دیدگاه مورفولوژی
- تاثیرنشانگ رهای غیرتهاجمی بزاق در تشخیص سرطان دهان
- بررسی میزان فراوانی بیماری فاویسم در کودکان زیر۶ سال در شهر بوشهر
- بررسی تاثیرپاالیندگی گیاه Salsola crassa بر کاهش آلودگیفاضلاب صنعتی
اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.