Synthesis and Characterization of Linear-Dendritic Macromolecules as the New Reducing Agents and Biocompatible Nanocarriers

  • سال انتشار: 1388
  • محل انتشار: سومین کنفرانس نانوساختارها
  • کد COI اختصاصی: CNS03_010
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 1868
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نویسندگان

Ashkan Tavakoli Naeini

Department of Chemical and Petroleum Engineering, Sharif University of Technology, Tehran, Iran

Mohsen Adeli

Institute for Nanoscience and Nanotechnology, Sharif University of Technology Department of Chemistry, Faculty of Science, Lorestan University, Khoramabad

Manouchehr Vossoughi

bInstitute for Nanoscience and Nanotechnology, Sharif University of Technology

چکیده

Poly (citric acid)- poly (ethylene glycol)-Poly (citric acid) (PCA-PEG-PCA) triblock copolymers(ABA- type) as biocompatible compounds were synthesized in three different molecular weights and applied as nanocarriers and reducing agents as well. Gold nanoparticles (AuNPs) were encapsulated within the above-synthesized linear-dendritic copolymers. Protected metal nanoparticles by PCA-PEG-PCA were stable in water for several months and agglomeration was not occurred. Characterizations of the macromolecules and nanoparticles were carried out using different spectroscopy methods. Diameter of the synthesized copolymers was investigated using transmission electron microscopy (TEM) and dynamic light scattering (DLS) experiments experiments and it was between 1.8 and 2.5 nm for the three different molecular weights. The size of AuNPs and also reducing ability and loading capacity of the linear–dendritic nanocarriers were investigated within a simultaneously reduction reaction of the HAuCl4 and encapsulation of AuNPs by using UV-visible spectroscopy and TEM It was found that the loading capacity of PCA-PEG-PCA macromolecules directly depends on the size of dendritic citric acid parts whereas there is an inverse relationship between the PCA PEG-PCA molecular weight and the size of synthesized AuNPs.

کلیدواژه ها

Citric acid; Poly (ethylene glycol); Linear-dendritic; Gold nanoparticles; Loading capacity

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