Therapeutic Effect of Hydatid Cyst Liquid on Melanoma Tumor Growth in Mouse Model

Introduction: Hydatid cyst is the larval stage of Echinococcus granulosus which develops invarious human and livestock animals tissues. This hydatid cyst composed of several layers.Previous investigations have shown that the prevalence of hydatid cyst in cancer patients issignificantly lower than in healthy individuals. In animal models preventive effect of the hydatidcyst antigens in reduction of tumor growth has been shown. Due to the effect of live protosculexand hydatid cyst antigens on reducing the growth of cancer cells in culture medium, in this studytherapeutic effect of hydatid cyst liquid on the growth of melanoma tumor in mice (C57 black) hasbeen investigated.Materials Methods: In this Experimental study, the population studies were C57 black mice. Sixgroups of mice were injected with 106 melanoma cells in their chest site subcutaneously. Then themice were injected with hydatid cyst fluid either with or without albendazole. From the secondweek, the tumor size was measured using calipers and tumor area was calculated and the meantumor area compared with those of control groups using One-way ANOVA test.Results:The mean tumor area, in groups which injected with hydatid cyst fluid (case groups), wasless than the mean tumor area in the control groups and this difference was statistically significant.Conclusion: This study showed that hydatid cyst fluid may have therapeutic effect on melanomacancer growth.