Management of cytarabine-induced palmar erythrodysesthesia in case of lymphoma

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 366

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شناسه ملی سند علمی:

ISMOH17_045

تاریخ نمایه سازی: 10 اردیبهشت 1398

چکیده مقاله:

Introduction: Hand-foot syndrome (HFS) has been reported in patients treated with traditionalsystemic chemotherapeutic agents such as 5-fluorouracil, doxorubicin, cytarabine,cyclophosphamide, vinorelbine and those treated with targeted therapies such as sunitinib. Wereport palmar erythrodysesthesia after chemotherapy with high dose cytarabine in case oflymphoblastic lymphoma that was resolved within week after giving topical olive oil,antihistamine and short course of low dose dexamethasone.Case Report :A22 y/o female case of Precursor cell lymphoblastic lymphoma was admitted toreceive chemotherapy (Cycle B) with continuous infusion of MTX 1000 mg/BSA with leucovorinrescue and high dose cytarabine (4400 mg over hours q12 hour on days 2, 3) in sun protecteddark, clean room. She has been received Hyper-CVAD regimen (Cycle A) month ago withoutany serious complication.1 days after completion of cytarabine she developed bilateral palmarerythrodysesthesia.Treatment with Local olive oil for palms, Oral hydroxyzine 10 mg TDS and Dexamethasone mgIV (that was repeated after hours) was initiated .Palms pain and edema were markedlydiminished after 12hours and palmar erythema was resolved during week.Result: We saw rapid recovery of cytarabine induced palmar erythrodysesthesia after using topicalolive oil, oral antihistamine and intravenous dexamethasone.Conclusion: Local olive oil, antihistamines and short course of low dose dexamethasone can helpfor rapid recovery of HFS

نویسندگان

Nasim Valizadeh

Assistant professor of Hematology/Medical Oncology, Department of Internal Medicine, Faculty ofMedicine, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran Hematologist/Medical Oncologist, Golestan Hospital, Tehran, Iran