Jafar Mehvari Habibabadi - Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Mohamad Zare - Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Nasim Tabrizi - Department of Neurology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Background: Sleep Seizures (SSs) generally occur in refractory focal epilepsy, but their detailedcharacteristics and circadian patterns are still controversial. The effect of SSs on epilepsy surgeryoutcome has been addressed in few studies without definitive prognostic value.Objectives: This study investigated the characteristics of SSs and their prognosis in refractoryfocal epilepsy.Materials & Methods: This retrospective cross-sectional study was conducted in the referralepilepsy center in Isfahan, Iran from 2011 to 2015. It investigated SSs in patients with refractoryfocal epilepsy who underwent pre-operative evaluation. Demographic data, electroclinical findings,pathology, and postsurgical outcomes were analyzed and compared to Wake Seizures (WSs).Before the main analysis, Shapiro-Wilk test of normality was performed. Then the Independentsample t test, Chi-square test, Fisher’s exact test, Mann-Whitney U test and 1-way ANOVA wereused to analyze the obtained data in SPSS. All probability tests were two-tailed and the level ofsignificance was defined as P≤0.05.Results: A total of 371 seizures in 113 patients were studied. The sleep/wake seizure ratio inTemporal Lobe Epilepsy (TLE) and Extratemporal Lobe Epilepsy (ETLE) were 0.54 and 0.91,respectively. The peak incidence of SSs in TLE and ETLE were during 4.00 to 8.00 and 0.00 to4.00, respectively. SSs were considerably associated with EEG changes before clinical signs. IctalEEG localization was more successful in SSs of extratemporal origin. Based on pathology findings,Focal Cortical Dysplasia (FCD) was highly associated with SSs. Left epileptogenic zone and FCDaccompanied a less favorable outcome in SSs.Conclusion: SSs are significantly more frequent in patients with ETLE and follow specificcircadian patterns based on epileptogenic zone. Seizure semiology and EEG findings are in favor ofmore localized onset of epileptic activity in SSs of extratemporal origin. The side of epileptogeniczone, circadian pattern of seizures, well-defined epileptogenic lesion in MRI and pathology, couldaffect postsurgical outcomes in SSs.

Circadian rhythm, Sleep, Epilepsy