Research Paper: Tapering Oral Steroid Treatment After IV Methylprednisolone Pulse Therapy in Demyelinating OpticNeuritis
محل انتشار: علوم اعصاب کاسپین، دوره: 4، شماره: 12
سال انتشار: 1397
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 389
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شناسه ملی سند علمی:
JR_CJNS-4-12_001
تاریخ نمایه سازی: 18 اسفند 1397
چکیده مقاله:
Background: Optic neuritis is an inflammation of the optic nerve. Because of importance of visionfor human, management of optic neuritis is an important issue in neurology.Objectives: This study aimed at assessing the effect of oral steroid treatment after intravenous (IV)methylprednisolone therapy on demyelinating optic neuritis.Materials & Methods: 60 Patients with first episode of acute demyelinating optic neuritiswho referred to a neurology clinic in an academic hospital in south-west of Iran in 2015-2016included in this randomized double-blind clinical trial study (No: IRCT2015102724735N1). Theywere divided into two groups with (A) and without (B) tapering oral steroid treatment after IVmethylprednisolone. Visual acuity and color vision were measured before treatment, before oraltapering, 1 and 3 months after treatment. Independent t-test in SPSS software version 20 was usedto analyze the data. P<0.05 was considered as the level of significance.Results: Visual acuity in two groups did not have any significant difference in any time point ofassessment (P> 0.05).Frequency of color vision abnormality in groups A and B were at baseline(53.3% vs. 56.6%) (P=0.796), before oral tapering (43.3% vs. 30%, P=0.284), 1 month aftertreatment (23.3% vs. 30%, P=0.559), 3 months after treatment (0% vs. 23%, P=0.011).Conclusion: Oral steroid treatment after IV methylprednisolone pulse therapy improves colorvision after 3 months in patients with demyelinating optic neuritis but has no effect on visual acuity.
کلیدواژه ها:
نویسندگان
Seyed Ehsan Mohammadianinejad
Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Nastaran Majidinasab
Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Adel Nejati
Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Hamidreza Hatamian
Department of Neurology, Poursina Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran