Ali Shoeibi - MD, Department of Neurology, Faculty of medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Nilufar Razmi - MD, Department of Neurology, Faculty of medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Ali Ghabeli Juibary - MD, Department of Neurology, Faculty of medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Seyed Isaac Hashemy - MD, Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

Background: Among different mechanisms, oxidative stress has a possible role inneural injury in cerebrovascular events.Objectives: Assessment the oxidants-antioxidants imbalance in ischemic andhemorrhagic strokes.Materials and Methods: Serum level of malondialdehyde, the main marker oflipid peroxidation, and total antioxidant capacity were measured in a group of 48stroke patients consisting of 24 ischemic and 24 hemorrhagic cases withconfirmed diagnosis by brain CT scan. Lesion volume and modified NationalInstitutes of Health Stroke Scale (NIHSS) in ischemic stroke, as well as locationand volume of hematoma in hemorrhagic stroke based on the first brain CT scanwere determined as study variables.Results: These two major groups did not have different oxidative profile. Lowlevels of total antioxidant capacity and high levels of malondialdehyde wereassociated with higher lesion volume in hemorrhagic stroke patients.Conclusions: This data suggested that oxidative stress is associated with lesionvolume and therefore severity of hemorrhagic stroke.

Oxidative Stress; Malondialdehyde; Stroke