M. Babazadeh - Department of Chemistry, Islamic Azad University Tabriz Branche , Tabriz, Iran - Islamic Azad University Bostanabad Branch, Bostanabad, Iran
L. Edjlali - Department of Chemistry, Islamic Azad University, Tabriz Branch, Tabriz , Iran
S. Naserian - Department of Chemistry, Islamic Azad University, Tabriz Branch, Tabriz , Iran

In this research, 5-amino salicylic acid (5-ASA) as an important drug in treatment of inflammatory bowel diseases [1,2] was linked to 2-hydroxypropyl methacrylat by carbonyldiimidazole (CDI) to obtain metachryloyloxy propyl 5-amino salicylate. The resulting acrylic derivative of 5-ASA was copolymerized with 2-hydroxyethyl methacrylat and methyl metacrylat by free radical polymerization method in N,N-dimethyl formamid solution, utilizing benzoyl peroxide as an initiator at 70 °C. The obtained polymer was characterized by FT-IR and elemental analysis. Gel permeation chromatography was used for determination of average molecular weights of polymers bearing drug units as side substituents of the acrylic backbone. Release studies of 5-ASA were performed into dialysis bags by hydrolysis buffered solutions (pH 1, 7.4, 10) at 37 ºC . Detection of hydrolysis by UV spectroscopy at selected interval showed that the drug can be released by selective hydrolysis of the ester bond at the side of drug moiety. The release profiles indicated that the hydrolytic behavior of polymeric prodrugs is strongly based on the hydrophobicity of polymer and the pH of the hydrolysis solution.