The synthesis of 2-amino-4H-chromenes using L-proline as a catalyst
- سال انتشار: 1389
- محل انتشار: همایش منطقه ای شیمی
- کد COI اختصاصی: MIAUCHEMISTRY01_086
- زبان مقاله: انگلیسی
- تعداد مشاهده: 304
نویسندگان
Islamic Azad University, Karaj Branch ,Department of Science, Karaj, Iran
Islamic Azad University, Karaj Branch ,Department of Science, Karaj, Iran
Islamic Azad University, Takestan Branch, Department of Science, Takestan, Iran
چکیده
2-Amino-4H-pyrans are an important class of heterocyclic compounds having important biological activities. During the last decade, such compounds had shown interesting pharmacological properties including antimicrobial, antiviral, mutagenicity, antiproliferative, sex pheromone, antitumor, cancer therapy, and central nervous system activity [1]. Multi-component reactions (MCRs) constitute an especially attractive synthetic strategy for rapid and efficient library generation due to the fact that the diversity can be achieved simply by varying the reacting components [2]. A mixture of resorcinol, malononitrile, aldehyde, and L-proline in ethanol were stirred. After completion of the reaction (monitored by TLC, ethyl acetate/n-hexane 1:1), the solvent was evaporated under reduced pressure, water and ethanol were added to the reaction mixture, and the resulting solid was separated by filtration. The resulting chromenes were charctersized IR and 1H-NMR.کلیدواژه ها
مقالات مرتبط جدید
اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.