The Synthesis and characterization of 2-methoxy-4-(2H-tetrazol-5-yl)phenol

Since the 1980s, the growth of tetrazole chemistry has continued unabated due to its popular functionality with a wide range of pplications . Tetrazoles have found use in pharmaceuticals, specialty eplosives, photography and information recording ystems , not to mention as precursors to a variety of nitrogen containing heterocycles. It has long been known that simpleh eating of azide salt with nitrile in a solution produces the corresponding tetrazole [1]. In this research work, we synthesized some new compounds of alkyl tetrazoles. Therefore, 4-hydroxy-3-methoxybenzaldehyd (1) in reaction with NH2OH was converted to 4-hydroxy-3-methoxybenzaldehyde oxime (2). The obtained compound was dehydrated by acetic anhydride to give 4-hydroxy-3-methoxybenzonitrile (3). Then, 2-methoxy-4-(2H-tetrazol-5-yl)phenol(4) was prepared by [2+3] cycloaddition reaction between (3) and NaN3.The structure of all the synthesized compounds were characterized and confirmed by FT-IR and NMR spectroscopy techniques.