Laparoscopy in Ovarian Cancer for selection Neoadjuvant Chemotherapy vs. Primary Cytoreductive Surgery

  • سال انتشار: 1397
  • محل انتشار: سومین کنگره بین المللی روش های کم تهاجمی زنان و مامایی ایران
  • کد COI اختصاصی: LAMOGMED03_115
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 435
دانلود فایل این مقاله

نویسندگان

Mojgan Karimi-Zarchi

Prof,Gynecolohist Oncologist,Iran University of Medical Science,Tehran,Iran

چکیده

Objective: Laparoscopy has also been reported on for staging in early ovarian cancer. The aim of this study is to evaluate the results of laparascopy for selection of neoadjuvant chemotherapy (NACT) and the impact of interval debulking surgery (IDS) on clinical outcomes of patients with advanced-stage ovarian cancer.Methods: We performed a retrospective analysis on 92 patients with advanced ovarian cancer admitted to ValiAsr Gynecologic oncology departments during 1996–2012. Comparison was made with results of laparscopy for selection of patients for neoadjuvant chemotherapy of 24 patients with unresectable advanced epithelial ovarian cancer treated with platinum- based NACT followed by IDS and clinical outcomes of 68 consecutive stage III and IV ovarian cancer patients treated with primary cytoreduction followed by platinum-based adjuvant chemotherapy. Results: Primary cytoreductive surgery caused longer survival compared to neoadjuvant chemotherapy. Patients who underwent optimal interval debulking surgery (IDS) had a better progression free survival (PFS) (p=0.002) and overall survival (p=0.03)than those who did not. There were not significant differences between the two groups in complications of surgery. Conclusion:laparascopy for selection of NACT followed by successful IDS can lead to high survival percentage in patients with chemoresponsive advanced ovarian cancer; although the result is more effective in those with optimal primary cytoreduction, we still got the same results with those with suboptimal primary cytoreduction.

کلیدواژه ها

Ovarian cancer,advance disease, neoadjuvant chemotherapy,interval debulking surgery,cytoreductive surgery,outcome

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.