Pre-Transplantation Platelet Count and Hemoglobin Level Can Predict RBC and Platelet Transfusion Requirement in Allogeneic-Hematopoietic Stem Cell Transplantation

Background and Aim: Allogeneic-hematopoietic stem cell transplantation(Allo-HSCT) is the selected treatment for patients with a variety ofmalignant and nonmalignant disorders. The conditioning regimenbefore HSCT can affect the hematopoietic system, therefore the patients received packed RBC and platelet until engraftment occurs. The aim ofthis study was to determine the relationship between hemoglobin (Hb)level and platelet count before transplantation as an index for predictingthe requirement of RBC and platelet unit after allogeneic-HSCTMethods: This retrospective study includes 196 patients withhematological malignancies who underwent allogeneic HSCT at bonemarrow transplantation center of Taleghani hospital between 2008 to2017. The Hb level and platelet count of the patients were quantifiedbefore allo-HSCT and the data of the RBC/platelet requirement of patientswere obtained from patients’ files. The correlation between the plateletcount and Hb level with received packed RBC and platelet units afterallo-HSCT were assessed using the Pearson correlation test.Results: The results indicated a significant positive correlation betweenthe pre-transplantation Hb level with RBC transfusion requirement afterallo-HSCT (P= 0.02) but the pre-transplantation platelet count did nothave a correlation with the transfused platelet units after allo-HSCT(P=0.07). According to our data patients with lower Hb levels beforetransplantation received RBC more often after HSCT than the patientswith higher pre-transplantation Hb levels.Conclusion: Regarding the results, It seems that the Hb level beforeallo-HSCT can be used as a predictive marker of RBC requirement inallogeneic hematopoietic stem cell transplantation so that the patientswith low levels of Hb are more susceptible for more transfusion supportafter HSCT. The platelet count might be lesser important to be measuredbefore transplantation than Hb.

کلیدواژه ها:

Allogeneic hematopoietic stem cell transplantation ، RBC transfusion ، Platelet Transfusion ، Hemoglobin ، Platelet count