Evaluation of Gene Expression of LncRNA BC012900 in Patients with Inflammatory Bowel Disease

Background and Aim: Inflammatory bowel disease (IBD) is a multifactorialinflammatory disease that contains Crohn’s disease (CD) andulcerative colitis (UC). Incidence and prevalence of IBD are increasinggeographically around the world. Long noncoding RNAs (lncRNAs) wererecently identified to have a key role in regulating biological functionsin human disease. Although the exact role of lncRNAs in IBD remainsunknown, it is determined that the expression of some lncRNAs ischangeable in IBD. We aimed to evaluate the expression of BC012900lncRNA in patients with IBD CD and UC.Methods: In this study, BC012900 lncRNA in intestinal blood and tissuesamples were detected by quantitative real-time PCR. We performed thistest in 53 patients including 20 people with ulcerative colitis (UC), 13people with Crohn s disease (CD) and 20 normal people as the control.Results: In this study, we identified a widespread dysregulation of lncRNAin both CD and UC patients compared to the normal controls. We foundthat lncRNA BC012900 expression was elevated in IBD patients (P <0.05). This upregulated of BC012900 lncRNA was different in UC andCD patients, UC patients showed significantly a higher expression ofBC012900 (P< 0.0001) in compared CD patients (P=0.0078).Conclusion: Our data present that lncRNA BC012900 is involvedin inflammatory bowel disease patients, which provide a potentialprognostic biomarker and therapeutic targets.

کلیدواژه ها:

Inflammatory bowel disease ، Crohn’s disease ، Ulcerative colitis ، BC012900