Nanoencapsulation of Rosa Damascena Mill L. Extract Enhanced Its Local Analgesic Effects on Cornea of Rats.

Background and Aim: Rosa damascena mill L. extract (RDE) is commonlyknown as Gole Mohammadi in Iran is widely used as cosmeticand pharmaceutical adjuvant because of its analgesic, antibacterial,antioxidant and anti-inflammatory properties. In order to enhance thebioavailability of RDE, niosomes encapsulating RDE were prepared andexamined for topical analgesic properties on the cornea.Methods: RDE-loaded liposomes were formulated and characterizedin terms of their morphology zeta potential and entrapment efficiency.The niosomes were a diameter of less than 150 nm and remainedwell dispersed for at least 2 weeks. The obtained RDE niosomes wereexamined for analgesic effects on rat cornea before application ofhypertonic saline. Corneal and retinal tissues were evaluated under alight microscope after H&E staining.Results: Niosomal RDE significantly showed more analgesic potentialthan RDE alone. In addition, compared to the free niosome, RDEniosomes significantly increased the analgesic efficacy. Accordingly, thehistological results coreanal care properties of RDE will be significantlyenhanced by niosome encapsulation and also no retinal side effects wereobserved.Conclusion: The present niosomal RDE should have a great potential asan effective natural formulation for induction of corneal local analgesia.

کلیدواژه ها:

Rosa damascena extract ، Nanostructures ، Analgesia ، Cornea ، Topical ، Rats