ANRIL Gene Polymorphism Association with Acute Myeloid Leukemia (AML) in Iranian Population
- سال انتشار: 1397
- محل انتشار: سومین جشنواره ملی و کنگره بین المللی علوم و فناوری های سلول های بنیادی و پزشکی بازساختی
- کد COI اختصاصی: NSCMRMED03_183
- زبان مقاله: انگلیسی
- تعداد مشاهده: 402
نویسندگان
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
چکیده
Background and Aim: Recently, in an effort to fully illustrate theunderlying genetic causes of the acute myeloid leukemia (AML), attentionhas been devoted to the newest aspect of gene expression regulationswhich inferred to the regulatory lncRNAs. ANRIL is one of the diseaseassociatedlncRNAs which is transcribed from the pivotal genomic regionthat has an important role in the expression regulation of its neighborgenes CDKN2A and CDKN2B encoding 3 main tumor suppressor genesp14ARF, p15INK4b and p16INK4a.Methods: Since the identified variants in the CDKN2A and CDKN2Bgenes or ANRIL locus are indicated to be associated with pathogenicityin different diseases, we investigate ANRIL (rs10757278) singlenucleotide polymorphism in Iranian AML patients in comparison tocontrol individuals.Results: The results showed significant association neither for allelicand genotypic frequencies nor for haplotype blocks with AML patientsagainst healthy control.Conclusion: Considering the indicated roles of ANRIL in epigenetic geneexpression regulation, seeking its AML-associated genetic defects or itsabnormal expression in patients is still a growing area of research andfurther investigations may illustrate its potential to serve as a diagnosticbiomarker for AML.کلیدواژه ها
ANRIL; lncRNA; AMLمقالات مرتبط جدید
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