HLA-A Needs More Attention in Graft-Versus-Host Disease
- سال انتشار: 1397
- محل انتشار: سومین جشنواره ملی و کنگره بین المللی علوم و فناوری های سلول های بنیادی و پزشکی بازساختی
- کد COI اختصاصی: NSCMRMED03_143
- زبان مقاله: انگلیسی
- تعداد مشاهده: 336
نویسندگان
Hematopoeitic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Department of Immunology, Iran University of Medical Sciences, Tehran, Iran
Hematopoeitic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
چکیده
Background and Aim: Class I human leukocyte antigens (HLAs) have an important role in many kinds of transplantation specially allogeneichematopoietic stem cell transplantation (aHSCT) in which all majorHLA-I members (HLA-A, -B, -C) must be matched between the donorand recipients. Due to the cost, routine HLA-typing is low resolutionand despite the donor-recipient fully matched HLA-I, some post-aHSCTcomplication such as graft-versus-host disease might occur. In this study,we investigated the question that whether any matched HLA-I membershas an association with GvHD.Methods: In this retrospective study, the data of low-resolution HLA-Ityping of 190 patients who underwent aHSCT as well as their GvHDstatus were obtained from their clinical records. All patients receivedHLA-A, -B, -C fully matched hematopoietic stem cells. The associationbetween the types of HLA-I with GvHD status of patients were analyzedusing multivariate analysis.Results: Among the patients, only the patients with donor-recipientmatched HLA-A*01 have significantly high rate of acute GvHD (aGvHD)(P value= 0.048, RR=1.31) and significantly mortality rate (P value=0.04, RR= 1.21). Other donor-recipient matched class-I HLAs have nosignificant association with aGvHD and mortality. None of HLA-I have asignificant association with chronic GvHD.Conclusion: In accordance with the results, It seems that the HLA-Amight be more important in post-aHSCT complications especially lifethreateningaGvHD and should be typed with high-resolution methods.کلیدواژه ها
Human leukocyte antigen; HLA-I; GvHD; Mortalityمقالات مرتبط جدید
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