Nanofibrous Three Dimensional Scaffold Produced by Freeze-Drying from Ternary Composition: Polyvinyl Alcohol, Vinyl-BasedPolymer, and Nano-Graphene Oxide; for Bone Tissue Engineering
- سال انتشار: 1397
- محل انتشار: سومین جشنواره ملی و کنگره بین المللی علوم و فناوری های سلول های بنیادی و پزشکی بازساختی
- کد COI اختصاصی: NSCMRMED03_122
- زبان مقاله: انگلیسی
- تعداد مشاهده: 364
نویسندگان
Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Fatemeh Sadat Tabatabaei Mirakabad
Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
چکیده
Background and Aim: The present work aims to obtain new nanofibrous biocomposites based on polyvinyl alcohol (PVA) reinforced with vinylbased polymer (VBP) and nano-graphene oxide (nGO) by freeze-dryingas a candidate for bone tissue engineering. On the one hand, thescaffolds are designed with consideration of the high implementationof the aforementioned biopolymers as biomaterials; on the other hand,the two component of the system, GO and VBP, is expected to improveporosity, biocompatibility structural stability and boost mechanicalstrength. Moreover, a 3D porous structure made out of nanofibersfabricated through the freeze-drying process.Methods: We prepare two solutions of polymers:1) Polyvinyl alcohol,Vinyl based polymer, and Nano-graphene oxide (NP+), 2) Polyvinylalcohol, Vinyl based polymer (NP–). Then fabricate 3D hydrogelcomposites through the controlled freeze-drying process. The scaffoldswere characterized by Fourier-transform infrared spectroscopy (FT-IR),thermogravimetric analysis (TGA) and scanning electron microscopy(SEM). Furthermore, the mechanical properties, biocompatibility, andcytocompatibility of PVA-VBP-nGO (NP+) and PVA-VBP (NP–) scaffoldwere explored.Results: FT-IR showed the absorption regions of the specific chemicalgroups associated with PVA, VBP, GO in NP+ hydrogel group and PVA,VBP in NP– hydrogel group. Incorporation of nGO greatly improved thethermal resistance, mechanical stability, and cytocompatibility of theNP+ nanocomposite scaffold as compared to NP- composite scaffold.SEM analysis showed that the presence of nanofibers in the structure ofthe above mention groups. It is also found that using of nGO resulted inmore uniformly nanofibers in NP+ 3-dimensional group.Conclusion: In this study, for the first time, we introduced the fabricationof new PVA-VBP-nGO nanofibers 3D scaffolds through the freezedryingprocess which could serve as an efficient construct for bone tissueengineering.کلیدواژه ها
Nanofibrous three-dimensional scaffold; Polyvinyl alcohol; Nano-graphene oxide; Bone tissue engineeringمقالات مرتبط جدید
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