Efficacy and Safety of Chitosan-Based Bio-Compatible Dressing Versus Nanosilver (Acticoat) Dressing in the Treatment of Recalcitrant Diabetic Wounds

Background and Aim: Chitosan has a biocompatible, biodegradable,and nontoxic nature. The effectiveness of nano-chitosan films in the fieldof wound healing has been confirmed previously. Nanosilver (acticoat)dressing has also been used for the treatment of different wounds formany years. To compare the clinical efficacy and safety of two dressings(chitosan and nanosilver dressings) in the treatment of refractory diabeticwounds.Methods: A total of 25 eligible patients with chronic non-healingdiabetic wound were included and randomly assigned to receivechitosan (13 patients) or nanosilver (12 cases) dressing. The dressingswere applied on the wounds based on their protocols and patients werevisited and examined by an experienced dermatologist every week. Theclinical assessments and healing rates were recorded using diabetic footinfection (DFI) score at the 2nd, 4th, 6th weeks during treatment. Thestudy endpoint (the time needed for complete improvement), safety andtolerability profile were also documented.Results: The patterns of change in total 10-item DFI wound scores didn’tdiffer significantly over time between the two groups. In both groups, thetotal 10-item DFI wound score reduced continuously through the courseof study. The mean percentage reduction of the total 10-item DFI woundscore from baseline was 78.1% and 74.1% in the chitosan and nanosilverdressing groups, respectively. Both dressings were well tolerated and there were no product-related adverse events such as allergic reactionor infection.Conclusion: Our findings confirmed that chitosan can be safely andeffectively used for the treatment of diabetic wounds just like thenanosilver (acticoat) dressing. Further studies are recommended todesign a randomized clinical trial with more volunteers.

کلیدواژه ها:

Chitosan ، Diabetic wounds ، Nanosilver