Synthesis, FT-IR Spectra and DFT calculations of indazolo phthalazinetrione derivatives
محل انتشار: بیست و یکمین کنفرانس شیمی فیزیک انجمن شیمی ایران
سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 477
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شناسه ملی سند علمی:
ISPTC21_175
تاریخ نمایه سازی: 30 دی 1397
چکیده مقاله:
Heterocyclic chemistry is one of the most important fields in organic chemistry. Heterocyclescontaining the phthalazine ring are main object in synthetic and medicinal chemistry becausethey have many biologically actives. Multicomponent reactions of dimedone, an aldehyde, andN-nucleophilic heterocycles have recently attracted interest as different condensation productscan be obtained depending on the specific conditions and structure of the building blocks.Wereported an efficient method for the synthesis of indazolo phthalazinetrione derivatives by a fourcomponentcondensation reaction of dimedone, aromatic aldehydes and hydrazine monohydrateand 3-nitrophthalic anhydride in the presence of a catalytic amount of Zr(NO3)2. 2H2O in ethanolin conditions of reflux. Sterically congested 2,2-disubstituted indane-1,3-dione derivatives havebeen synthesized and characterized by 1HNMR, 13CNMR and FT-IR and elemental analysis. TheB3LYP/HF calculations for computation of FT-IR spectra have been carried out for the titlecompounds. Predicted vibrational frequencies have been assigned and compared withexperimental FT-IR spectra and they are supported each other.
کلیدواژه ها:
نویسندگان
Forozan Pirvaei
Address: Department of Chemistry, Zanjan Branch, Islamic Azad University, Zanjan, Iran
Nahid Shajari
Department of Chemistry, Zanjan Branch, Islamic Azad University, Zanjan, Iran
Hoorye Yahyaei
Department of Chemistry, Zanjan Branch, Islamic Azad University, Zanjan, Iran