Majid Hajifaraji - Research Associate Prof., Department of Food and Nutrition Policy and Planning Research, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Neda Dolatkhah - Assistant Prof., MD, PhD. Nutrition, School of Medicine Tabriz University of Medical Sciences, Iran
Fatemeh Abbasalizadeh - Assistant Prof., MD, Gynecologist, School of Medicine, Tabriz University of Medical Sciences, Iran
Naser Aghamohammadzadeh - Assistant Prof., MD, Endocrinologist, School of Medicine, Tabriz University of Medical Sciences, Iran

Despite achieved progress in the control and treatment of pregnant women with gestational diabetes mellitus (GDM), these patients are still at risk of disease complications. The aim of present study was to investigate the effect of probiotic supplement on systolic blood pressure (SBP) and diastolic blood pressure (DBP) among GDM pregnant women.In this randomized double-blind, placebo-controlled trial 64 pregnant women with GDM were assigned into two groups and received probiotic capsule (n=32) or placebo (n=32) for 8 weeks. Blood pressures were measured at baseline and 2 weeks intervals and up to 8 weeks.56 subjects were analyzed at the end of the study. After 8 weeks, SBP didn’t differ significantly in probiotic group at any time checkpoint but increased significantly in placebo group. DBP changes in a trend in probiotic group was obvious after 2 weeks and was reducing towards, however in placebo group, there was a tendency for higher DBP after week 6. There were significant differences between two groups of study after 6 weeks in the terms of SBP[104.828 (2.051) mmHg vs. 112.963 (2.126) mmHg , p=0.008 and 106.552(1.845)mmHg vs. 115.185(1.912)mmHg, p=0.002, in weeks 6 and 8 respectively] and DBP [62.414 (1.353) mmHg vs. 70.741 (1.402) mmHg , p<0.001and 60.690 (1.540)mmHg vs. 71.296 (1.596)mmHg, p< 0.001, in weeks 6 and 8 respectively].Conclusion: The results demonstrated that taking probiotic supplements for 8 weeks in patients with GDM prevented the increase of SBP and resulted in reduction of DBP after 2 weeks of consumption.

Probiotic; Supplement; Gestational Diabetes Mellitus; Blood Pressure