EFFECT OF SUPPLEMENTATION OF VITAMIN D, C AND E ON THE LUNG FUNCTIONAL TESTS, LEVELS OF HS-CRP, ESR, TGFΒ1 AND ANTIOXIDANT STATUS IN IDIOPATHIC PULMONARY FIBROSIS PATIENTS

Background and Aim: Idiopathic pulmonary fibrosis is one of the most important chronic respiratory diseases. One of the causes of its occurrence and exacerbation is imbalance in the antioxidant and inflammatory system. The aim of this study was to evaluate the effect of supplementation of vitamins on biochemical and functional lung tests in adults with pulmonary fibrosis.Methods: thirty tree patients (women=55%) participated in this quazi experimental for 3 months and supplemented with E, C and D vitamins (200 IU/day, 250 mg/day and 50000IU doses respectively). At the beginning and end of study Demographic, anthropometric measurements, biochemical tests, and lung function by spirometry and plethysmography investigated. Moreover, Food intake 24-recall, Physical activity, sun exposure and St. George s Respiratory Questionnaire evaluated.Results: The results obtained from biochemical tests represents a significant increase in vitamin C (P <0.001) and D (P = 0.016) levels while vitamin E (P = 0.055) has no significant changes. We observed a decrease in, hs-CRP and TGFβ1 (p<0.001) and Protein carbonyl (P = 0.034), while changes in GPX activity (P = 0.737) wasn’t significant. Increase in percent of FEV1 (p= 0.016), IRV (P = 0.001), RV (P = 0.002) and TLC (P = 0.003) and changes in FVC, VC, FEV1/FVC and ERV were not significant. And St. George s Respiratory Questionnaire has shown a significant increase. There was no significant difference in confounding variables.Conclusion: It seems that taking 3 months of D, C and E vitamins in patients with lung fibrosis has a significant effect on respiratory function and inflammatory/anti-oxidant profiles.

کلیدواژه ها:

pulmonary fibrosis ، vitamins ، inflammatory factors ، oxidative stress