EFFECTS OF FLAXSEED SUPPLEMENTS ON INFLAMMATORY BIOMARKERS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF CONTROLLED CLINICAL TRIAL
- سال انتشار: 1397
- محل انتشار: سومین کنگره بین المللی و پانزدهمین کنگره تغذیه ایران
- کد COI اختصاصی: INC15_482
- زبان مقاله: انگلیسی
- تعداد مشاهده: 423
نویسندگان
Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
چکیده
Background and Aim: Many experimental and clinical trials suggested that flaxseed might be a potent anti-inflammatory agent, but the evidences concerning the effects of flaxseed supplements on inflammation has not been fully conclusive. We aimed to assess the impact of the effects of flaxseed supplements on inflammatory biomarkers through systematic review of literature and meta-analysis of available randomized controlled trials (RCTs).Methods: The literature search included PUBMED, Cochrane Library, Scopus, and EMBASE up to February 2015 to identify RCTs investigating the effect of flaxseed supplements on plasma blood pressure. Effect size was expressed as weighed mean difference (WMD) and 95% confidence interval (CI).Results: 31 trials with 1502, which included 936 in intervention group and 566 in control group were included in this meta-analysis. Random-effects meta-analysis suggested significant reductions in CRP (WMD=-0.56 [95% CI: -1.03, -0.10], p = 0.02), hs-CRP (mean difference=-0.69 [95% CI: -1.22, -0.16], P=0.01), and TNF- (WMD=-0.38 [95% CI: -0.75, 0.01]; P =0.07 ) following supplementation with flaxseed products. We could not found any significant reduction in IL-6 concentration after flaxseed intake IL-6 (WMD=-0.25 [95% CI: -0.70, 0.21]; P =0.28). However, sensitivity analysis for IL-6 suggests a significant change in the results following the exclusion one of the study. For all biomarkers, heterogeneity between studies was high and when the studies were stratified according to their duration, supplement dose and study quality, source of the heterogeneity identified. Conclusion: Our results showed that flaxseed or its derivatives can have anti-inflammatory effects in the human bodyکلیدواژه ها
flaxseed, inflammation, inseed; meta-analysis; systematic reviewمقالات مرتبط جدید
- Lactic Acid Bacteria Probiotics in The Prevention of Gestational Diabetes: Mechanistic Insights and Potential Long-Term Cancer Risk Reduction
- وضعیت تغذیه و عادات غذایی در بیماران مبتلا به سندرم خوردن شبانه
- The Role of Holistic Pharmacy in Cancer Patient Care
- Oral Health, Periodontal Disease, Oral Microbiome and Stroke Risk: Mechanisms and Translational Potential
- نقش مداخلات تغذیه ای مبتنی بر پروبیوتیک ها و پری بیوتیک ها در بهبود سلامت روده و پیشگیری از بیماری های متابولیک
اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.