EFFECTS OF COENZYME Q10 SUPPLEMENTATION ON SERUM ADIPONECTIN LEVELS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS

Background and Aim: Adiponectin, a well-known adipokine plays a number of regulatory actions in human body metabolism. Decreased levels of adiponectin have been reported in type 2 diabetes mellitus, cardiovascular diseases, metabolic syndrome and hypertension. Coenzyme Q10 (Co Q10) is a fat-soluble antioxidant substance which have been reported to be effective in several metabolic disturbance such as insulin resistance and inflammation. Present systematic review and meta-analysis was performed to assess the effects of CoQ10 supplementation on adiponectin serum level. Methods: A comprehensive search was performed in electronic databases including EMBASE, Google scholar, and Pubmed up to January 2018 limited to English. A meta-analysis of eligible studies was performed using random effects model to estimate pooled effect size of CoQ10 supplementation on adiponectin.A total of 209 subjects were recruited from 5 eligible studies. Meta-analysis did not suggest any significant effect of CoQ10 supplementation on adiponectin serum level (0.240 mg/dl, 95%CI: -0.216, 0.696, P= 0.303). Because there was no significant heterogeneity between studies (I2= 40.9%, p= 0.149) subgroup analysis were not performed. Conclusion: In conclusion, the present meta-analysis of 5 randomized clinical trials did not indicate any significant effects of CoQ10 supplementation on serum adiponectin levels. Future long-term dose-response trials are needed to evaluate the exact effect of CoQ10 supplementation on circulating adiponectin.

کلیدواژه ها:

Adiponectin ، Coenzyme Q10 ، Supplementation ، Meta-analysis ، Review