ASSOCIATION OF WRIST CIRCUMFERENCE WITH CARDIO-METABOLIC RISK FACTORS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF OBSERVATIONAL STUDIES

Background and Aim: 7Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, IranMethods: We systematically searched PubMed/Medline, Web of Sciences and Scopus electronic databases, without language limitation until March 2017. Pooled association of WrC with metabolic syndrome (MetS) was estimated using random-effect model and heterogeneity between studies was assessed using I2 and Q test.Results: Finally, 14 papers met the criteria and included. The eligible papers examined the association of WrC with any cardiovascular disorders (n=8), metabolic syndrome (n=4), insulin resistance (IR) (n=5), diabetes mellitus (n=2), impaired glucose tolerance (n=1), cardio-metabolic risk factors (n=2) and obesity/ overweight (n=1). In whole population (pediatric and adults population), high WrC increased the risk of MetS 33% (OR: 1.33; 95% CI: 1.20, 1.48; I2=60.2%, p=0.04). While in adult populations the pooled OR was 1.27 (95% CI: 1.15- 1.41; I2:32.8%, p=0.21). Qualitative synthesis showed that association between WrC with other cardio-metabolic risk factors are conflicting.Conclusion: High WrC increased the risk of MetS and other cardio-metabolic risk factors. However, due to limited studies, particularly in children findings should be declared with great caution. Further cohort studies are needed to clarify that WrC is a suitable anthropometric index to predict cardio-metabolic disorders in adult and children populations in different societies.

کلیدواژه ها:

Wrist circumference ، metabolic syndrome ، cardiovascular diseases