EFFECT OF ALPHA-LIPOIC ACID SUPPLEMENTATION ON LIPID PROFILE: A SYSTEMATIC REVIEW AND META-ANALYSIS OF CONTROLLED CLINICAL TRIALS

Background and Aim: Several studies have shown the effect of alpha-lipoic acid on lipid profile parameters. However, findings remain controversial. This systematic review and meta-analysis was done to systematically summarize the available clinical trials that examined the effects of alpha-lipoic acid supplementation (ALA) on lipid profile among adults.Methods: A systematic search through PubMed and Scopus was done for English published studies up to April 2017. Effect sizes were combined with fixed- or random-effects analysis, where appropriate. Between-study heterogeneity was evaluated by Cochran’s Q test and I2.Results: Totally, 11 clinical trials with 452 subjects (51.5% women, 48.5% men) were included in this meta-analysis. Combining effect sizes of 10 studies on serum TG concentrations revealed a significant effect of ALA supplementation on serum TG, as compared to the placebo group (WMD: -29.185 mg/dl; 95% CI: -51.454 to -6.916, p= 0.010). We also found significant changes in serum TC and LDL (WMD: -10.683 mg/dl; 95% CI: -19.816 to -1.550, p= 0.022, WMD: -12.906 mg/dl; 95% CI: -22.133 to -3.679, p= 0.006, respectively). While significant changes were not observed in serum HDL (WMD: -0.092 mg/dl; 95% CI: -3.014 to 2.831, p= 0.025). Supplementation dosage and BMI were potential sources of heterogeneity, in which those who received more than 600 mg/day alpha-lipoic acid with BMI greater than 30 showed better improvements in lipid profile. Conclusion: Our findings showed that supplementation with ALA significantly decreased the serum concentrations of TG, TC, and LDL but did not affect serum levels of HDL in adults.

کلیدواژه ها:

Supplementation ، Alpha-lipoic acid ، ALA ، Lipid profile ، Meta-analysis