EFFECT OF L-CITRULLINE SUPPLEMENTATION ON BLOOD PRESSURE: A SYSTEMATIC REVIEW AND META-ANALYSIS OF CLINICAL TRIALS
- سال انتشار: 1397
- محل انتشار: سومین کنگره بین المللی و پانزدهمین کنگره تغذیه ایران
- کد COI اختصاصی: INC15_345
- زبان مقاله: انگلیسی
- تعداد مشاهده: 500
نویسندگان
Seyed mohammad Sadegh Mirenayat
Students’ Research Committee, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
Students’ Research Committee, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran
Department of Community Nutrition, School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
Department of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center,Isfahan University of Medical Sciences, Isfahan, Iran
چکیده
Background and Aim: Several interventional studies assessed the impact of dietary supplements on blood pressure. The aim of the present systematic review and meta-analysis was to determine the efficacy of L-citrulline supplementation on blood pressureMethods: Pubmed, Scopus, Google Scholar and ISI Web of Science were comprehensively searched until May 2018 to assess whether L-citrulline reduces blood pressure. Human clinical trials which reported the effect of L-citrulline supplementation on aortic and brachial blood pressure were included. Characteristics of studies and potential sources of heterogeneity were tabulated. A subgroup analysis was performed to attenuate observed inter-study heterogeneity. Results: A total of five interventions were found for meta-analysis. The impact of L-citrulline on brachial systolic (Change: 0.28 mmHg; 95% CI: -2.87, 2.31 mmHg) and diastolic (Change: -1.56 mmHg; 95% CI: -4.32, 1.20 mmHg) blood pressure was not significant. Also, there was no changes in aortic systolic (Change: 0.22 mmHg; 95% CI: -4.81, 4.38 mmHg) and diastolic (Change: 0.26 mmHg; 95% CI: -2.27, 2.80 mmHg) blood pressure after L-citrulline supplementation. Participants body weight status was a source of observed heterogeneityConclusion: The present systematic review and meta-analysis suggests that L-citrulline supplementation had no beneficial effect on blood pressureکلیدواژه ها
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