THE EFFECTS OF VITAMIN D3 SUPPLEMENTATION ON SOME METABOLIC AND INFLAMMATORY MARKERS IN DIABETIC NEPHROPATHY PATIENTS WITH MARGINAL STATUS OF VITAMIN D: A RANDOMIZED DOUBLE BLIND PLACEBO CONTROLLED CLINICAL TRIAL

سال انتشار: 1397
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 274

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شناسه ملی سند علمی:

INC15_178

تاریخ نمایه سازی: 30 دی 1397

چکیده مقاله:

Background and Aim: Diabetic nephropathy is known to be an independent risk factor in the progression of renal and cardiovascular disorders. Due to the association between vitamin D deficiency and diabetic nephropathy, vitamin D deficiency in the diabetic nephropathy population, this study conducted to examine the effects of Vitamin D3 on metabolic and inflammatory parameters in patients with diabetic nephropathy.Methods: This eight-week, randomized, double-blind, placebo-controlled trial was carried out on 50 diabetic nephropathy patients with marginal status of vitamin D. Participants were randomly assigned to two groups: control and intervention. Participants received a vitamin D3 (50000 IU) supplement weekly on a specific day. Fasting blood samples were collected from all patients at their entry to the study, and eight weeks after interventionResults: Analyses showed significance differences in physical activity between the intervention and placebo groups (P=0.018). There were no significant differences between the percentage changes of HbA1c, insulin and, inflammatory parameters such as TNF-α and IL-6 (P> 0.05), while the percentage change of FBS was significantly higher in the placebo group compared to the treatment one (p<0.0001). Lower levels of FBS (p<0.0001), insulin (p<0.069), HOMA-IR (p<0.001), TNF-α (p<0.002) and IL-6 (p<0.037) were found after supplementation in treatment group. However, the phosphorous and protein percentage change in urine were lower (p=0.07) and higher (p=0.003) between groups.Conclusion: It was found that vitamin D supplementation can be regarded as an effective way to prevent the progression of diabetic nephropathy by reducing levels of proteinuria, and inflammatory markers such as TNF-α and IL-6

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نویسندگان

Asra Esfandiari

Student, School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, I. R. Iran

Bahram Pourghassem GarGgari

Professor of Nutrition Science, Nutrition Research Center, Department of Biochemistry and Diet Therapy,Faculty of Nutrition and Food Sciences Tabriz University of Medical Sciences, Tabriz, I. R. Iran

Hamid Noshad

Professor of nephrology, Chronic Kidney Disease Research Center, Tabriz University of Medical Sciences,Tabriz, I. R. Iran

Parvin Sarbakhsh

Assistant Professor of Biostatics, Department of Statistics and Epidemiology, Tabriz University of Medical sciences, Tabriz, I. R. Iran