Maryam Alinezhad-Namaghi - Mashhad University of Medical Sciences
Saeid Eslami - Mashhad University of Medical Sciences
Mohsen Nematy - Mashhad University of Medical Sciences
Adeleh Khoshnasab - Mashhad University of Medical Sciences

Background and Aim: Time-restricted feeding (TRF) is a kind of Intermittent fasting that defines as eating only during a certain number of hours each day. It has been suggested that intermittent fasting can improve cardiovascular risk factors. This study was conducted to evaluate the effect of intermittent fasting on pulse wave velocity (PWV) and pulse wave analysis (PWA) indices (as the Arterial stiffness indices) in metabolic syndrome volunteers.Methods: This was a cohort study that was carried out among adult volunteers with metabolic syndrome, before and after Ramadan (as an intermittent fasting) in Mashhad, Iran. Volunteers classified to fasting and not fasting groups (based on at least 10 days of fasting during this fasting period). The aortic pulse wave velocity and central aortic pressure waveform were detected. Central systolic pressure, central pulse pressure and indices of arterial stiffness (such as augmentation pressure and augmentation index) were provided from analysis of the waveform. Results: Ninety five adult metabolic syndrome volunteers (65 male and 30 female with the mean age of 45.4± 9 years) participated in this study. This study showed a significant reduction in PWV, central systolic pressure, central pulse pressure, central augmentation pressure and central augmentation index in fasting group. There was no significant change in these arterial stiffness indices among not fasting group.Conclusion: This study suggested that intermittent fasting may be considered as a strategy for arterial stiffness improvement in metabolic syndrome volunteers.

intermittent fasting, arterial stiffness, pulse wave velocity