THE SYNERGISTIC EFFECTS OF Ω-3 FATTY ACIDS AND NANO-CURCUMIN SUPPLEMENTATION ON TUMOR NECROSIS FACTOR (TNF)-Α GENE EXPRESSION AND SERUM LEVEL IN MIGRAINE PATIENTS

  • سال انتشار: 1397
  • محل انتشار: سومین کنگره بین المللی و پانزدهمین کنگره تغذیه ایران
  • کد COI اختصاصی: INC15_062
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 380
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نویسندگان

Mina Abdolahi

AmirAlam Hospital Complex, Marvasti hospital, Tehran University of Medical Sciences, Tehran, Iran

Mohsen sedighiyan

Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

Arash Jafarieh

AmirAlam Hospital Complex, Marvasti hospital, Tehran University of Medical Sciences, Tehran, Iran

چکیده

Background and Aim: in migraine pathogenesis, TNF-α increase prostanoid production, hyperexcitability of neurons, and nociceptor activation resulted in neuroinflammation and neurogenic pain. ω-3 fatty acids and curcumin exert neuroprotective and anti-inflammatory effects via several mechanisms including suppression of TNF-α gene expression and its serum levels. The aim of this study is an evaluation of synergistic effects of ω-3 fatty acids and nano-curcumin on TNF-α gene expression and serum levels in migraine patients. Methods: The present study performed as a clinical trial over a 2 month period included 74 episodic migraine patients in 4 groups and received ω-3 fatty acids, nano-curcumin, and combination of them or placebo. At the start and the end of the study, the gene expression of TNF-α and TNF-α serum levels was measured by real-time PCR and ELISA method, respectively.Results: Our results showed that the combination of ω-3 fatty acids and nano-curcumin downregulated TNF-α messenger RNA (mRNA) significantly in a synergistic manner (P < 0.05). As relative to gene expression, a significant greater reduction in serum levels of TNF-α were observed in the combination group, but no significant differences in other groups. Supplementation with ω-3 fatty acids or nano-curcumin alone did not show significant reduction either in mRNA or serum levels of TNF-α. In addition, a much greater reduction in attack frequency was found in the combination group (P < 0.001).Conclusion: These findings indicated that ω-3 fatty acids and curcumin supplementation can be considered as a new promising approach in migraine management.

کلیدواژه ها

Curcumin; Gene expression; Migraine; TNF-α; ω-3 fatty acids

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