EFFECT OF QUERCETIN ON COLON CANCER IN RAT

سال انتشار: 1397
محل انتشار: سومین کنگره بین المللی و پانزدهمین کنگره تغذیه ایران
کد COI اختصاصی: INC15_041
زبان مقاله: انگلیسی
تعداد مشاهده: 410

نویسندگان

Department of Community Nutrition Faculty of Nutrition and Food Sciences’ Tabriz University of Medical Sciences’ Tabriz’ Iran

چکیده

Background and Aim: Quercetin is an anti-oxidative flavonoid widely distributed in the plant kingdom. Quercetin is commonly present as a glycoside and is converted to glucuronide/sulfate conjugates during intestinal absorption and only conjugated metabolites are therefore found in circulating blood. Although metabolic conversion attenuates its biological effects, active aglycone may be generated from the glucuronide conjugates by enhanced b-glucuronidase activity during inflammation Methods: The present study is designed to investigate the preventive effects of polymeric quercetin on colon carcinogenesis in an azoxymethane-induced rat tumor. thirty rats were equally divided into healthy, control-and quercetin -treated groups. Animals received azoxymethane (AOM) as a carcinogenic agent (15 mg/kg, s.c.) weekly for two consecutive weeks. They were given quercetin (10 mg/kg, s.c.) two weeks before till 12 weeks after the last injection of AOM. In the end, histopathological and immunohistochemistry examinations were performed on colon tissueResults: The cytological and morphological changes of the cells healthy group were significantly lower compared to other groups (P< 0.05). The mean number of lesions, nuclear/cytoplasmic ratio, epithelial stratification, loss of nuclear polarity, goblet depletion, structural abnormality and beta-catenin expression were higher in the control group compared to quercetin groups.(P< 0.05)Conclusion: The present study demonstrated the potential anticancer effects quercetin in a typical animal model. The results provide evidence that quercetin exerts a significant chemopreventive effect on AOM-initiated colon cancer through cell proliferation inhibition. More investigations are needed to confirm its safety for human use

کلیدواژه ها

Colon Cancer, Quercetin, Beta-catenin

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