THE EFFECT OF ORAL MAGNESIUM SUPPLEMENTATION ON MICRO-ALBUMINURIA AND METABOLIC STATUS OF PATIENTS WITH DIABETIC NEPHROPATHY: A DOUBLE-BLIND RANDOMIZED CONTROLLED CLINICAL TRIAL

  • سال انتشار: 1397
  • محل انتشار: سومین کنگره بین المللی و پانزدهمین کنگره تغذیه ایران
  • کد COI اختصاصی: INC15_036
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 686
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نویسندگان

Mehdi Sadeghian

Students Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran

Leila Azadbakht

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran

Noushin Khalili

Isfahan Kidney Diseases Research Center, Department of Nephrology, Isfahan University of Medical Sciences, Isfahan, Iran.

Mojgan Mortazavi

Associate Professor of Endocrinology, Department of Internal Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

چکیده

Background and Aim: Low serum magnesium concentrations were associated with development of renal failure. We aimed to determine whether magnesium supplementation improves renal function, insulin resistance and metabolic profiles in patients with diabetic nephropathy.Methods: A total of 40 hypomagnesaemic patients diagnosed with type 2 diabetes and early-stage nephropathy were recruited. Subjects received either daily Magnesium oxide or placebo for 12 weeks. Biochemical and anthropometric variables were measured. Physical activity and dietary intakes were also recorded. This study was approved by the ethics committee of Isfahan University of Medical Sciences and was registered on the Iranian Registry of Clinical Trials website (IRCT registration no. IRCT201404271485N12).Results: Serum magnesium levels were not changed significantly. Although the supplementation did not influence glycemic indices, patients in the magnesium group had greater insulin resistance compared with placebo group after intervention (0.3 ± 2.3 µIU/mL vs. -0.04 ± 2.05, P = 0.04). No significant changes were observed in serum total cholesterol, triglycerides, HDL-, LDL- and total- cholesterol/HDL-cholesterol ratio. Furthermore, magnesium did not affect inflammation, serum levels of creatinine and blood urine nitrogen. However, a marginal decrease in microalbuminuria (-3.1 ± 2.2 mg/L vs. -14 ± 9.9, P=0.09) was observed.Conclusion: Oral magnesium supplementation slightly improved microalbuminuria but resulted in increased insulin resistance in patients with diabetic nephropathy.

کلیدواژه ها

Diabetic nephropathy, Insulin resistance, Magnesium, Microalbuminuria, Renal failure

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