Investigating of HER-2/Neu Expression in Gastric Cancer and Its Correlation with Histological Findings of Tumor

  • سال انتشار: 1397
  • محل انتشار: دومین کنگره بین المللی پزشکی افضلی پور
  • کد COI اختصاصی: AFZMED02_006
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 571
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نویسندگان

Mohammad Mahdi Hayatbakhsh Abbasi

Assistant Professor, Pathology and Stem Cells Research Center, Kerman University of Medical Sciences, Kerman, Iran.

Elham Jafari

Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran

Mohammad Javad Zahedi

Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran

Sodaif Darvish Moghaddam

Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.

چکیده

Background: In Cancer cells, HER-2/Neu acts as an oncogene. Its overexpression leads to increased protein in the membrane of cancer cells. The role of HER-2/Neu was known in awide variety of cancers such as breast and lung neoplasms. This study aimed to investigate HER-2/Neu expression in gastric cancer by using immunohistochemistry (IHC).Materials and methods: This cross-sectional study was performed on 48 individuals with gastric cancer who had undergone gastrectomy. After diagnosing gastric cancer byhistologic reports, the specimen were reassessed for HER-2/Neu evaluation. IHC was used to determine HER-2/Neu expression (Biogenax kit, DAKO criteria). Data were analyzedby descriptive and analytical methods and SPSS software version 20. Results: The study cases are comprised of 48 individuals (79.2% male). The average age of cases was 59.93 ±13.95 years. The mean of tumor size was 5.5±2.45 cm. The most common tumor location was antrum and pylorus (43.8%). Intestinal type of gastric cancer was the most common (72.9%). The most of cases were in stage T3 (87.5%). HER-2/Neu positive expression was present in 10.4%, while the majority of cases showed a HER2/Neu-negetive status (89.6%). There was no significant relationship between HER-2/Neu expression and investigated variables (p> 0.05). Conclusions: According to the results of this study, HER-2/Neu expression in gastriccancer was low. More extensive studies are needed

کلیدواژه ها

HER-2/Neu, Gastric Cancer, Immunohistochemistry, Gene Expression

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